Dimeres de pyrrolo(2,1-c) (1,4) benzodiazepine en tant qu'agents antitumoraux et procede correspondant

Pyrrolo[(2,1-c)(1,4) benzodiazepines dimers as antitumour agents and process thereof


The present invention provides Analogues of 1, 1'-{[(bisalkane-1,N-diyl)piperazine]dioxy}bis(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one] of formula (VI) where n = 2 to 10; a pharmaceutical composition comprising the above analogs and a process of preparing these analogues.
La présente invention concerne des analogues de 1,1'-{[(bisalkane-1,N-diyl)piperazine]dioxy}bis(11aS)-7-méthoxy-1,2,3,11a-tétrahydro-5H-pyrrolo[2,1-c] [1,4]benzodiazépin-5-one] répondant à la formule (VI) dans laquelle n vaut de 2 à 10, une composition pharmaceutique renfermant lesdits analogues, ainsi que leur procédé de préparation.




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